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AZD7762 Chk remmer
Cat.nr.S1532
Chemische structuur
Molecuulgewicht: 362.42
Spring naar
Kwaliteitscontrole
Batch:
Zuiverheid:
99.98%
99.98
Celkweek, behandeling & werkzame concentratie
| Cellijnen | Assaytype | Concentratie | Incubatietijd | Formulering | Activiteitsbeschrijving | PMID |
|---|---|---|---|---|---|---|
| KASUMI-1 | Growth Inhibition Assay | IC50=0.000234 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.000415 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000425 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00643 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.02849 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.03142 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.03251 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.03417 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.03442 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.03579 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.03896 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.04022 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.04316 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.04592 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.05158 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.06025 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.06102 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.06115 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=0.06136 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.06196 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.06255 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.0646 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.07146 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.0739 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.07486 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=0.07807 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.08421 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.08659 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.0871 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.08806 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.08807 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.09091 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.09903 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.09918 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.10033 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.102 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.11063 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.11093 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.1186 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.12165 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.1225 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.12484 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.12843 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.13041 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.13064 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.13128 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.1316 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.13325 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.13369 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.13476 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.1368 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=0.13687 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.13894 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13925 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.14288 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.14463 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=0.1469 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.14842 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.14967 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=0.15674 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.15786 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.15847 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.16011 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.16166 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.16311 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.16503 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.16535 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.1683 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.16847 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.17171 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.17464 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.17827 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.18599 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.18815 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.18905 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.19278 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.19561 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.19761 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.19782 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.19832 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.20117 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.20318 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=0.20873 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.2097 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.21429 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.22062 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=0.22068 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.22235 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.22298 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.22454 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22557 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.2257 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.22633 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.22666 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.23036 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.23056 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=0.23238 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.2385 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.24243 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.24339 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.24401 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.24451 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.24568 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.24626 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.24671 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24761 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=0.25654 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.25768 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.26064 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.27059 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=0.27089 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.27097 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.27304 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.27385 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.2798 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.2806 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.28134 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.28354 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.2868 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.2891 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.29008 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.29154 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.29279 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.29406 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29704 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.29793 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.29802 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.29845 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=0.29855 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.29896 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=0.30265 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=0.30431 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.30665 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.31525 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.31566 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.3165 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=0.31819 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.32021 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=0.32353 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.32489 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.32594 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=0.33142 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.33343 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.3381 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.34584 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.34596 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.34677 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.34682 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.34875 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.34887 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.35584 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.35696 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.36482 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.36985 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.37497 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.37606 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.37948 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.38353 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.38567 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.38712 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.38792 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.38823 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.3897 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.39118 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.40131 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.40151 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.40191 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.40286 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.41092 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.41172 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.41225 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.41661 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.41714 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=0.42138 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.42885 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.43049 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.43162 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.43288 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.44185 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.44187 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.44293 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.45103 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.45136 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.45278 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.45293 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.4546 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.45612 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=0.46294 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.46419 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.46603 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.46868 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.47035 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.48234 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.48626 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.4903 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.49115 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.4927 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.49921 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.49922 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.50633 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.51344 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.51437 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.52019 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.52114 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.52551 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.53078 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.53466 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.53657 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.53774 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.53881 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.54077 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.5558 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.55933 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.56326 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.56522 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=0.56553 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.57121 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.57421 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.57497 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.58162 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=0.58375 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.58382 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.58833 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.59118 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.59129 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=0.60328 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.61787 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.61861 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.6201 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.62788 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.63712 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.63721 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.64023 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.64935 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.65036 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.6565 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.65805 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.66068 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.66223 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.66361 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.67625 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.67671 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.67852 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.68306 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.68804 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.68928 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.69217 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.69812 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.70549 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.70631 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.70765 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.70781 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.72257 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.7262 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.73552 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.73593 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.73864 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=0.7403 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.74584 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.74806 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.74908 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.74968 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.74984 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.75456 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.76262 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.77355 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.77553 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.78211 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.78432 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.78939 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.7924 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.79651 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.80487 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.81349 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.81371 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.8244 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.82636 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.83474 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.83711 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.84484 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.84556 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.84591 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=0.85882 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.86185 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.86536 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.87334 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.87731 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.87995 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.88097 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.88602 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.89417 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.89777 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.90316 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.90578 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.90943 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.90984 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.91552 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.91852 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.92452 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.93251 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.93557 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.93665 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.94092 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.94127 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.94227 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.94237 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=0.96749 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.9696 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.97028 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.97945 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.98027 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.98378 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.98462 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.98473 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.98592 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.99258 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=1.00412 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=1.01813 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=1.01859 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=1.0352 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=1.03971 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=1.04 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=1.05075 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=1.05336 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=1.06828 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=1.07773 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=1.09352 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=1.10973 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=1.11785 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=1.12251 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=1.12291 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=1.14353 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=1.14714 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=1.1667 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=1.19347 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=1.19515 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=1.19819 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=1.21334 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=1.21367 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=1.21418 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=1.21478 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=1.21773 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=1.22758 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=1.23359 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=1.23525 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=1.24343 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=1.26666 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=1.26672 μM | SANGER | |||
| BT-549 | Growth Inhibition Assay | IC50=1.26782 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=1.2864 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=1.30672 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=1.32503 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=1.34551 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=1.37564 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=1.38168 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=1.39051 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=1.39501 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=1.39986 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=1.40231 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=1.41187 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=1.41795 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=1.41954 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=1.42018 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=1.42176 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=1.42257 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=1.43128 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=1.44319 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=1.46151 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=1.46382 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=1.48104 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=1.48613 μM | SANGER | |||
| A549 | Growth Inhibition Assay | IC50=1.48833 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=1.49026 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=1.4938 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=1.52313 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=1.52961 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=1.53706 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=1.5825 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=1.58328 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=1.60227 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.6038 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=1.60591 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.61345 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=1.63456 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=1.69256 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=1.69983 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=1.70067 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.71785 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=1.72407 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=1.72963 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=1.76749 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=1.77556 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=1.78642 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=1.80267 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=1.80853 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=1.81214 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=1.84746 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=1.8707 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=1.87342 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=1.88676 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=1.90787 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=1.90932 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.92035 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=1.99105 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=2.00154 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=2.00372 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=2.00898 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=2.04059 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.05442 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=2.07098 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=2.08603 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=2.10041 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=2.12541 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=2.13147 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=2.15307 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=2.17015 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=2.17788 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=2.19271 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=2.19369 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.19596 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=2.29973 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=2.32659 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=2.33868 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=2.34603 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=2.38204 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=2.38794 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=2.39805 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.43727 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=2.46994 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=2.50249 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=2.50305 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=2.52934 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=2.53747 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=2.61116 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=2.66161 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=2.66611 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=2.67374 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=2.70406 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=2.71627 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=2.71949 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=2.73756 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=2.86389 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=2.88431 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=2.92139 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=2.92257 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=2.99939 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=3.02636 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=3.03463 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=3.0671 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=3.09693 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=3.11827 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=3.12141 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=3.18474 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=3.2326 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=3.28489 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=3.29179 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=3.3281 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=3.44761 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=3.52417 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=3.53214 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=3.562 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=3.57986 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=3.59867 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=3.60009 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=3.81119 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=4.01396 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=4.23597 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=4.25191 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=4.29271 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=4.31345 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=4.352 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=4.41913 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=4.45528 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=4.52362 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=4.54871 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=4.71694 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=4.83841 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=4.84991 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=5.14506 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=5.14859 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=5.29782 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=5.44014 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=5.48022 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=5.66889 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=5.70345 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=5.7081 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=5.74182 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=5.74564 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=5.75333 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=5.77563 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=5.86894 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=6.24585 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=6.39403 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=6.79722 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=6.99591 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=7.12299 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=7.87127 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=8.02984 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=8.16024 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=8.28886 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=8.93093 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=9.03452 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=9.28844 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=9.33919 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=9.53596 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=10.0229 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=10.4369 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=10.5255 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=10.6852 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=12.3172 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=12.5284 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=12.6333 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=12.8771 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=13.2365 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=14.5461 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=14.8582 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=15.1741 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=15.4474 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=15.7611 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=16.0124 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=19.726 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=20.3577 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=20.7836 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=21.5541 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=23.4086 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=23.7673 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=25.571 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=27.8316 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=28.3248 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=28.4192 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=31.4912 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=32.8858 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=33.0843 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=33.5145 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=37.3585 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=40.6295 μM | SANGER | |||
| NCI-H1666 | Growth Inhibition Assay | IC50=42.4488 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=46.4196 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=48.1756 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=48.5026 μM | SANGER | |||
| Klik om meer experimentele gegevens over cellijnen te bekijken | ||||||
Chemische informatie, opslag en stabiliteit
| Molecuulgewicht | 362.42 | Formule | C17H19FN4O2S |
Opslag (vanaf de datum van ontvangst) | |
|---|---|---|---|---|---|
| CAS-nr. | 860352-01-8 | SDF downloaden | Opslag van stamoplossingen |
|
|
| Synoniemen | N/A | Smiles | C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N | ||
Oplosbaarheid
|
In vitro |
DMSO
: 73 mg/mL
(201.42 mM)
Water : Insoluble Ethanol : Insoluble |
Molariteitscalculator
Verdunningscalculator
Molecuulgewichtcalculator
|
In vivo |
|||||
In vivo formulatiecalculator (heldere oplossing)
Stap 1: Voer onderstaande informatie in (Aanbevolen: een extra dier om rekening te houden met verlies tijdens het experiment)
mg/kg
g
μL
Stap 2: Voer de in vivo formulering in (Dit is alleen de calculator, geen formulering. Neem eerst contact met ons op als er geen in vivo formulering is in de sectie oplosbaarheid.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Berekeningsresultaten:
Werkconcentratie: mg/ml;
Methode voor het bereiden van DMSO-moedervloeistof: mg geneesmiddel vooropgelost in μL DMSO ( Concentratie moedervloeistof mg/mL, Neem eerst contact met ons op als de concentratie de DMSO-oplosbaarheid van de batch van het geneesmiddel overschrijdt. )
Methode voor het bereiden van in vivo formulering: Neem μL DMSO moedervloeistof, voeg daarna toeμL PEG300, mengen en verhelderen, daarna toevoegenμL Tween 80, mengen en verhelderen, daarna toevoegen μL ddH2O, mengen en verhelderen.
Methode voor het bereiden van in vivo formulering: Neem μL DMSO moedervloeistof, voeg daarna toe μL Maïsolie, mengen en verhelderen.
Opmerking: 1. Zorg ervoor dat de vloeistof helder is voordat u het volgende oplosmiddel toevoegt.
2. Zorg ervoor dat u het/de oplosmiddel(en) in de juiste volgorde toevoegt. U moet ervoor zorgen dat de verkregen oplossing, bij de vorige toevoeging, een heldere oplossing is voordat u verdergaat met het toevoegen van het volgende oplosmiddel. Fysieke methoden zoals vortexen, ultrasoon of een warmwaterbad kunnen worden gebruikt om het oplossen te bevorderen.
Werkingsmechanisme
| Targets/IC50/Ki |
Chk1
(Cell-free assay) 5 nM
Chk2
(Cell-free assay) <10 nM
|
|---|---|
| In vitro |
AZD7762, een meer selectieve Chk1-remmer, remt de Chk1-fosforylering van een cdc25C-peptide door reversibel te binden aan de ATP-bindingsplaats van Chk1, met een IC50 van 5 nM en een Ki van 3,6 nM. Deze verbinding induceert celstop met een EC50 van 0,620 μM, en heft de door camptothecine geïnduceerde G2-arrest significant op met een EC50 van 10 nM, door de Chk1-afhankelijke afbraak van Cdc25A en de activering van Cyclin A te blokkeren. Het (300 nM) verbetert de antitumorale werkzaamheid tegen SW620 en tegen MDA-MB-231 door de GI50-waarden te verlagen van respectievelijk 24,1 nM en 2,25 μM naar 1,08 nM en 0,15 μM. Dit chemische middel vertoont cytotoxiciteit tegen een verscheidenheid aan neuroblastoom-cellijnen met p53 wild type, p53-mutatie, Mdm2-amplificatie of p14-deletie met IC50-waarden variërend van 82,6-505,9 nM. |
| Kinase Assay |
Chk1 Kinase Test
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|
Recombinant humaan Chk1 wordt tot expressie gebracht als een S-transferase fusie in insectencellen met behulp van een baculovirus vector en gezuiverd door affiniteitschromatografie. Een synthetisch peptidesubstraat (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) voor Chk1 wordt gesynthetiseerd. De uiteindelijke testconcentraties van peptide en ATP (koud + 40 nCi [33P]ATP) zijn respectievelijk 0,8 en 1 μM. Verschillende concentraties van deze verbinding, buffer die peptide en Chk1 kinase en ATP bevat, worden achtereenvolgens toegevoegd aan een 384-wells testplaat. De plaat wordt 2 uur geïncubeerd, de reactie wordt gestopt door toevoeging van buffer die EDTA en scintillatieproximiteitsassay-kralen bevat, en de platen worden afgelezen met behulp van een TopCount-lezer. Gegevensanalyse wordt uitgevoerd om een dosisrespons (IC50) te bepalen.
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| In vivo |
AZD7762 alleen bij 25 mg/kg vertoont weinig antitumorale activiteit bij de H460-DNp53 xenograftmuizen en SW620 xenograftmuizen, maar wanneer het in combinatie wordt toegediend, vertoont deze verbinding een significante antitumorale werkzaamheid bij de twee xenograftmuizen met een log celvernietiging van 0,9 of een behandeld/controlepercentage (%T/C) van 26, zelfs bij een lage dosis van 12,5 mg. De toediening van deze chemische stof in combinatie bij de H460-DNp53 xenograftrat remt het tumorvolume op een dosisafhankelijke manier met %T/C-waarden van 48 en 32 voor respectievelijk 10 en 20 mg/kg. Deze verbinding (25 mg/kg) in combinatie veroorzaakt volledige tumorregressie bij de SW620 xenograftmuizen, waarbij de %T/C significant toeneemt tot respectievelijk -66% en -67%. |
Referenties |
Toepassingen
| Methoden | Biomarkers | Afbeeldingen | PMID |
|---|---|---|---|
| Western blot | pChk1 / Chk1 / Wee1 / p21 / p53 |
|
29963769 |
| Growth inhibition assay | Cell viability |
|
23715154 |
Informatie over klinische proeven
(gegevens van https://clinicaltrials.gov, bijgewerkt op 2024-05-22)
| NCT-nummer | Werving | Aandoeningen | Sponsor/medewerkers | Startdatum | Fasen |
|---|---|---|---|---|---|
| NCT00937664 | Terminated | Cancer|Solid Tumors|Advanced Solid Malignancies |
AstraZeneca |
July 2009 | Phase 1 |
| NCT00473616 | Terminated | Advanced Solid Tumors|Cancer|Advanced Solid Malignancies |
AstraZeneca |
May 2007 | Phase 1 |
| NCT00413686 | Completed | Solid Tumors |
AstraZeneca |
December 2006 | Phase 1 |
Technische ondersteuning
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Veelgestelde vragen
Vraag 1:
If I want to use it for i.p. injection, can I use DMSO to dissolve this compound?
Antwoord:
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is considered a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate it for i.v. injection.
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