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Luminespib (NVP-AUY922) HSP remmer
Cat.nr.S1069
Chemische structuur
Molecuulgewicht: 465.54
Spring naar
Kwaliteitscontrole
Batch:
Zuiverheid:
99.97%
99.97
| Gerelateerde doelwitten | Akt Wnt/beta-catenin PKC ROCK Microtubule Associated Integrin Bcr-Abl Actin FAK Kinesin |
|---|---|
| Overig HSP Inhibitoren | Tanespimycin (17-AAG) Elesclomol (STA-4783) Ganetespib (STA-9090) Alvespimycin (17-DMAG) Hydrochloride VER-155008 Onalespib (AT13387) BIIB021 Zelavespib (PU-H71) HSP990 (NVP-HSP990) NVP-BEP800 |
Celkweek, behandeling & werkzame concentratie
| Cellijnen | Assaytype | Concentratie | Incubatietijd | Formulering | Activiteitsbeschrijving | PMID |
|---|---|---|---|---|---|---|
| NCI-SNU-16 | Growth Inhibition Assay | IC50=48.3142 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=24.9105 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=24.3812 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=23.5526 μM | SANGER | |||
| RT4 | Growth Inhibition Assay | IC50=23.3282 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=22.4813 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=21.1318 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=21.8779 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=19.7888 μM | SANGER | |||
| DV-90 | Growth Inhibition Assay | IC50=18.9945 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=18.5759 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=14.73 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=13.529 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=10.7511 μM | SANGER | |||
| CPC-N | Growth Inhibition Assay | IC50=11.007 μM | SANGER | |||
| SCC-3 | Growth Inhibition Assay | IC50=10.5679 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=9.93656 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=9.51835 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=8.51731 μM | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | IC50=9.16281 μM | SANGER | |||
| TT | Growth Inhibition Assay | IC50=8.33009 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=6.60349 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=6.09291 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=5.84792 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=5.83556 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=5.66443 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=5.61178 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=5.21251 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=5.10633 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=4.95203 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=4.78572 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=4.56147 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=3.36097 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=3.33897 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=3.18937 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=2.98602 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=2.82046 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=2.62019 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=2.78715 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=2.53929 μM | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | IC50=2.56706 μM | SANGER | |||
| HCC1143 | Growth Inhibition Assay | IC50=2.50658 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=2.53689 μM | SANGER | |||
| DG-75 | Growth Inhibition Assay | IC50=2.48576 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=2.36397 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=2.26795 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=2.26585 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=2.20293 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=2.22265 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=2.18098 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=2.0792 μM | SANGER | |||
| Caov-3 | Growth Inhibition Assay | IC50=2.00625 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=1.83412 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.87593 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=1.55522 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=1.58889 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=1.35738 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=1.35687 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=1.33339 μM | SANGER | |||
| TALL-1 | Growth Inhibition Assay | IC50=1.25165 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=1.20595 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=1.18349 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=1.1542 μM | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | IC50=1.10766 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=1.0693 μM | SANGER | |||
| NCI-H2227 | Growth Inhibition Assay | IC50=1.04981 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.99379 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=1.04657 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.8942 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.90304 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.85115 μM | SANGER | |||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=0.88475 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.81339 μM | SANGER | |||
| SNU-475 | Growth Inhibition Assay | IC50=0.79202 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.79925 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=0.77975 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=0.78831 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=0.77845 μM | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | IC50=0.76903 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.74868 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=0.71918 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.7436 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=0.71719 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.70229 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.67952 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.67335 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=0.65092 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=0.64726 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.63152 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.60435 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.57313 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.55984 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=0.55211 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.54117 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=0.52207 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.53869 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=0.51457 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=0.50367 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=0.4803 μM | SANGER | |||
| UACC-812 | Growth Inhibition Assay | IC50=0.46776 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.45145 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=0.44848 μM | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=0.4483 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=0.44528 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=0.44401 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=0.41784 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.41117 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=0.411 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.40872 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=0.36691 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=0.37637 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=0.3612 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.35715 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=0.35124 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.34923 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.34452 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=0.33389 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.33132 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.32348 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.31118 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=0.31099 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.31064 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=0.30639 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.29921 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=0.30089 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29837 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=0.29331 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.29431 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.2881 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.29304 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=0.28383 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=0.28174 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=0.27733 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.27613 μM | SANGER | |||
| NCI-H1618 | Growth Inhibition Assay | IC50=0.2751 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.27249 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.2722 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=0.27201 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.26905 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=0.26677 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=0.26603 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=0.2593 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.2535 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.25086 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=0.24694 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=0.24612 μM | SANGER | |||
| EFE-184 | Growth Inhibition Assay | IC50=0.24597 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=0.24282 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.24239 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24059 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=0.24014 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.23731 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=0.23841 μM | SANGER | |||
| NCI-H838 | Growth Inhibition Assay | IC50=0.23714 μM | SANGER | |||
| IM-9 | Growth Inhibition Assay | IC50=0.23476 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=0.22865 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=0.22994 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.22708 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=0.22376 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=0.22566 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=0.21826 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=0.21747 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.21803 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.20997 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=0.20211 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.2064 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.19975 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=0.19863 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.19893 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.19748 μM | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | IC50=0.18649 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=0.18696 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.18569 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=0.186 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.18493 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=0.1797 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.17807 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.17883 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.17678 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.17486 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=0.1738 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.17257 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=0.17367 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.17246 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.1716 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=0.17061 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.17114 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=0.1659 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=0.16471 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=0.16169 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.16304 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.15899 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=0.15836 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=0.15413 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.1568 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=0.15333 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=0.15218 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.14942 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.15169 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=0.14787 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.1448 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.14772 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=0.14472 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.14429 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=0.14426 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.14201 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.14101 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.14078 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=0.14037 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.13827 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=0.13965 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.13469 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=0.13588 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=0.13444 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.1343 μM | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | IC50=0.12869 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=0.13177 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.12699 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=0.12674 μM | SANGER | |||
| DMS-53 | Growth Inhibition Assay | IC50=0.12276 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.1246 μM | SANGER | |||
| C-4-II | Growth Inhibition Assay | IC50=0.1217 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.1212 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=0.11964 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.11831 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.11719 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=0.11466 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=0.11607 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.11195 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.11192 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.11108 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=0.11145 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=0.10899 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=0.1102 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=0.10817 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.10604 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=0.10483 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.10488 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.10431 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.10407 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.1021 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.10267 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=0.10176 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=0.09999 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.09861 μM | SANGER | |||
| MDA-MB-468 | Growth Inhibition Assay | IC50=0.09985 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.09721 μM | SANGER | |||
| IPC-298 | Growth Inhibition Assay | IC50=0.09644 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=0.09601 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=0.09541 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=0.09505 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=0.09518 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=0.09444 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.09345 μM | SANGER | |||
| EVSA-T | Growth Inhibition Assay | IC50=0.09265 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.0931 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.09218 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.09193 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=0.09215 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.09082 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=0.08991 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.08968 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=0.08855 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.08763 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=0.08498 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.08759 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.08368 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.08345 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=0.08271 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.08158 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.08165 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.08028 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=0.08156 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=0.07984 μM | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | IC50=0.07992 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000558 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=0.000125 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.00138 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=0.000842 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.00237 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.00186 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.00318 μM | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.00297 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.00266 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.00325 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=0.00449 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.00336 μM | SANGER | |||
| MES-SA | Growth Inhibition Assay | IC50=0.00452 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=0.00489 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=0.00485 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.00458 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.00518 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.00518 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.00547 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.00607 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.00591 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.00631 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.0063 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.00641 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=0.00638 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.00695 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.00663 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.00749 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=0.00703 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.00814 μM | SANGER | |||
| EW-7 | Growth Inhibition Assay | IC50=0.00754 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.00821 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00852 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=0.0084 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.00826 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.00852 μM | SANGER | |||
| SNG-M | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.00859 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.00938 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.00922 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.00945 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.01017 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00952 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.01025 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.01017 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.0103 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=0.0103 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.01059 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.01053 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.01064 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.01061 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.01071 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=0.01086 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=0.01077 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.01073 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.01102 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=0.01129 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=0.0116 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.01154 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=0.01179 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.01162 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=0.01202 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.01192 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.01261 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.01204 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.01263 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.01281 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.01272 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.01269 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.01293 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.0129 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.01293 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.01299 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.01308 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=0.01302 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.013 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=0.01336 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=0.01331 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=0.01336 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.01339 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.01366 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.01349 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.01371 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.0137 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.01384 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.01382 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.01399 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=0.01442 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.01432 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.01466 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.01499 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.01502 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.01509 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.01542 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.01514 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.01509 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=0.01586 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.01581 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.01643 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.01593 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.01646 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.01657 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.01653 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.01651 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=0.01685 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.01681 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.01702 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.01697 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.01715 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.01709 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=0.01724 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.01721 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.01735 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=0.0174 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.01736 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.01751 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.01758 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.01755 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=0.01775 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.01758 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.01788 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.01812 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.01807 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=0.01874 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.01846 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.01911 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.01884 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.01915 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.01912 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.01934 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=0.01939 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=0.0195 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.01987 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.01977 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=0.01957 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=0.02004 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.02024 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=0.02026 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.02031 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.02037 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=0.0205 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=0.02055 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=0.02059 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.02115 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.02117 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.02115 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.0212 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.02122 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.02145 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.0215 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.02171 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.02188 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.02214 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.02212 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=0.02241 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.0228 μM | SANGER | |||
| MFE-296 | Growth Inhibition Assay | IC50=0.02322 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=0.023 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.02323 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.02328 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.02329 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.02345 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.02401 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.02431 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.02433 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=0.02435 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=0.02466 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=0.02475 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.02549 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=0.02555 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.0257 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=0.02576 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.02593 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.02607 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.02613 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=0.02639 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.02646 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.02658 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.02668 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.02664 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.02677 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.02713 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=0.0271 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.02723 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.02724 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.02755 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.0276 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=0.02785 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.02796 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=0.02801 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.02806 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=0.02809 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=0.02852 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.0286 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.02887 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.02929 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.02945 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.02954 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.02955 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.02961 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.03007 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=0.03012 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=0.03014 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=0.03016 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=0.03018 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.03072 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=0.03048 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.03107 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.03125 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.03177 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.03219 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.03217 μM | SANGER | |||
| NCI-H1734 | Growth Inhibition Assay | IC50=0.0323 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.03221 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.03281 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.03289 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=0.0329 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=0.03367 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.03374 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.03383 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=0.03376 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.03388 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.03396 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=0.03389 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.03401 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.03426 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.03479 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.03538 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=0.03507 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.03608 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=0.03608 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.03613 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.03614 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=0.03617 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.03642 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=0.03663 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.03671 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.03684 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.03731 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.03747 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.03771 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=0.03789 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.03784 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=0.03812 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.03858 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.03842 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.03891 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.03872 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.03893 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.03933 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.03935 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.0395 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.03961 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.04031 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.04069 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.04114 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.0411 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.04116 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.04141 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.04157 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.04161 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.04169 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=0.04191 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.04171 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.04212 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.04227 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.04237 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.04241 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.04241 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.04272 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.04292 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.04283 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.04297 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.0433 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.04341 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.04357 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.04362 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.04407 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.04375 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.0444 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.04456 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=0.0449 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=0.04569 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.0457 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.04581 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=0.0459 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.04609 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=0.04763 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.04771 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=0.04782 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.04802 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.04803 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=0.04827 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.04826 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=0.0489 μM | SANGER | |||
| COLO-205 | Growth Inhibition Assay | IC50=0.04919 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=0.0493 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.0493 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.0495 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.0501 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=0.05052 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.05031 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=0.05176 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.05311 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.05384 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=0.05387 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=0.05395 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=0.0543 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.05452 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=0.05525 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=0.05531 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.05588 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.05683 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=0.05596 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.05683 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.05715 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=0.05733 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=0.05743 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.05734 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=0.05749 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.05802 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=0.0587 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.05872 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=0.05876 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.05879 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=0.05896 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=0.05988 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=0.06082 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.06178 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.06189 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.0623 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=0.06303 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.0627 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.06328 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.06586 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=0.06597 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=0.06604 μM | SANGER | |||
| BOKU | Growth Inhibition Assay | IC50=0.06674 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.06745 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=0.0676 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.06901 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.06918 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=0.0692 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=0.07035 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.07143 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=0.07061 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.07161 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.07172 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=0.07241 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=0.07285 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.07287 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=0.07329 μM | SANGER | |||
| Calu-1 | Growth Inhibition Assay | IC50=0.07332 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=0.07382 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.07426 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.07421 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.07456 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.07505 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=0.07526 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=0.07565 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.07535 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.07648 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.07597 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=0.07704 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.07711 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.07716 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=0.07733 μM | SANGER | |||
| DMS-153 | Growth Inhibition Assay | IC50=0.07735 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.07799 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.07868 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.07888 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.07887 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=0.07965 μM | SANGER | |||
| Klik om meer experimentele gegevens over cellijnen te bekijken | ||||||
Chemische informatie, opslag en stabiliteit
| Molecuulgewicht | 465.54 | Formule | C26H31N3O5 |
Opslag (vanaf de datum van ontvangst) | |
|---|---|---|---|---|---|
| CAS-nr. | 747412-49-3 | SDF downloaden | Opslag van stamoplossingen |
|
|
| Synoniemen | AUY-922, VER-52296 | Smiles | CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C | ||
Oplosbaarheid
|
In vitro |
DMSO
: 93 mg/mL
(199.76 mM)
Ethanol : 31 mg/mL Water : Insoluble |
Molariteitscalculator
Verdunningscalculator
Molecuulgewichtcalculator
|
In vivo |
|||||
In vivo formulatiecalculator (heldere oplossing)
Stap 1: Voer onderstaande informatie in (Aanbevolen: een extra dier om rekening te houden met verlies tijdens het experiment)
mg/kg
g
μL
Stap 2: Voer de in vivo formulering in (Dit is alleen de calculator, geen formulering. Neem eerst contact met ons op als er geen in vivo formulering is in de sectie oplosbaarheid.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Berekeningsresultaten:
Werkconcentratie: mg/ml;
Methode voor het bereiden van DMSO-moedervloeistof: mg geneesmiddel vooropgelost in μL DMSO ( Concentratie moedervloeistof mg/mL, Neem eerst contact met ons op als de concentratie de DMSO-oplosbaarheid van de batch van het geneesmiddel overschrijdt. )
Methode voor het bereiden van in vivo formulering: Neem μL DMSO moedervloeistof, voeg daarna toeμL PEG300, mengen en verhelderen, daarna toevoegenμL Tween 80, mengen en verhelderen, daarna toevoegen μL ddH2O, mengen en verhelderen.
Methode voor het bereiden van in vivo formulering: Neem μL DMSO moedervloeistof, voeg daarna toe μL Maïsolie, mengen en verhelderen.
Opmerking: 1. Zorg ervoor dat de vloeistof helder is voordat u het volgende oplosmiddel toevoegt.
2. Zorg ervoor dat u het/de oplosmiddel(en) in de juiste volgorde toevoegt. U moet ervoor zorgen dat de verkregen oplossing, bij de vorige toevoeging, een heldere oplossing is voordat u verdergaat met het toevoegen van het volgende oplosmiddel. Fysieke methoden zoals vortexen, ultrasoon of een warmwaterbad kunnen worden gebruikt om het oplossen te bevorderen.
Werkingsmechanisme
| Targets/IC50/Ki |
HSP90α
(Cell-free assay) 13 nM
HSP90β
(Cell-free assay) 21 nM
|
|---|---|
| In vitro |
Luminespib (NVP-AUY922) remt de proliferatie van verschillende menselijke kankercellijnen in vitro, met een gemiddelde GI50 van 9 nM. De IC50-waarden van deze verbinding vallen in het bereik van 2 tot 40 nM in deze maagkankercellijnen. De IC50-waarde voor de BEAS-2B-cellen is 28,49 nM. Behandeling ermee beïnvloedt de expressie van HSP90 niet, maar de expressie van HSP70 wordt verhoogd door NVP-AUY922-behandeling. Het verhoogt de binding van HSP70 aan HSP90. Deze verbinding veroorzaakt p23-dissociatie van het HSP90-complex en kan vervolgens HSP70 rekruteren naar het HSP90-complex. Na de behandeling ermee is de expressie van receptortyrosinekinasen, waaronder VEGFR1, 2, 3 en PDGFRɑ, verlaagd. Een daling wordt ook opgemerkt in de expressie van Akt en fosfo-Akt. Ondertussen veroorzaakt behandeling met NVP-AUY922 een verminderde expressie van HER-2 in NCI-N87-cellen. Het resulteert in de binding van HSP90 aan cliëntproteïnen en stelt deze in als doelwitten voor afbraak door het proteasoom. Deze verbinding kan de celgroei beïnvloeden door meerdere signaalroutes te beïnvloeden. Bovendien herstelt behandeling met de proteasoomremmer, MG132, de expressie van thymidylaatsynthase, die erdoor wordt verminderd. Het verhoogt de expressie van gekliefde caspase-3, wat leidt tot apoptosis in HSC-2-cellen.
|
| Kinase Assay |
Kinase assay
|
|
Luminespib (NVP-AUY922) wordt opgelost in DMSO in een concentratie van 10 mM en wordt getest tegen HSP90α, HSP90β, GRP94, TRAP-1, HSP72 en topoisomerase II. Profilering tegen een panel van kinasen is uitgevoerd, en screening tegen een panel van additionele enzymen en receptoren wordt uitgevoerd bij Cerep.
|
|
| In vivo |
Luminespib (NVP-AUY922) veroorzaakt een robuuste antitumorrespons en remt de p-Akt- en VEGF-expressie in een HSC-2-xenograftmodel. In BT474 toont het een volledig verlies van ERBB2 en een aanzienlijke uitputting van ERα, naast reducties in CDK4 en fosfo-ERK1/2.
|
Referenties |
|
Toepassingen
| Methoden | Biomarkers | Afbeeldingen | PMID |
|---|---|---|---|
| Western blot | p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII E-cadherin / Cleaved PARP / Bim HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK CDK4 / HMGA2 |
|
23993685 |
| Growth inhibition assay | Cell viability |
|
26893968 |
Informatie over klinische proeven
(gegevens van https://clinicaltrials.gov, bijgewerkt op 2024-05-22)
| NCT-nummer | Werving | Aandoeningen | Sponsor/medewerkers | Startdatum | Fasen |
|---|---|---|---|---|---|
| NCT01772797 | Completed | Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer |
Novartis Pharmaceuticals|Novartis |
June 2013 | Phase 1 |
| NCT01752400 | Completed | Non Small Cell Lung Cancer |
Massachusetts General Hospital |
January 2013 | Phase 2 |
| NCT01613950 | Completed | Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein |
Novartis Pharmaceuticals|Novartis |
December 2012 | Phase 1 |
| NCT01484860 | Terminated | Adenocarcinoma of the Pancreas|Metastatic Disease |
University Health Network Toronto|Novartis Pharmaceuticals |
January 2012 | Phase 2 |
| NCT01402401 | Terminated | Advanced Gastric Cancer |
Novartis Pharmaceuticals|Novartis |
November 2011 | Phase 2 |
Technische ondersteuning
Tel: +1-832-582-8158 Ext:3
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