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APC remmers (APC Inhibitors)

Anaphase-Promoting Complex (APC) which is also called cyclosome, a highly conserved protein, plays a key role in both cell cycle and Ubq degradation pathway. The APC can results in degradation of specific proteins which are involved in cell cycle by tagging those proteins during the transition from metaphase to anaphase. When spindle checkpoint is silenced, APC can easily bind to Cdc20 after phosphorylated by M-Cdks. Then APC targets cyclin A and cyclin B for degradation.

Overige Cell Cycle Inhibitoren

CDK ROCK Wee1 Aurora Kinase Chk PLK MPS1 Rho Myc DYRK
Cat.nr. Productnaam Informatie Citaties van productgebruik Productvalidaties
S2225 TAME Tosyl-L-Arginine Methyl Ester (TAME) is een APC-remmer.
Dev Cell, 2023, 58(3):192-210.e11
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
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S9605 Apcin Apcin (APC-remmer) is een remmer van de E3 Ligase-activiteit van het mitotische anaphase-promoting complex/cyclosome (APC/C) dat bindt aan Cdc20 en de ubiquitilatie van D-box-bevattende substraten competitief remt.
Nature, 2025, 647(8091):952-961
Theranostics, 2025, 15(8):3439-3461
Cell Mol Biol Lett, 2025, 30(1):29