Home JAK/STAT -Epigenetics Pim Pim3 Inhibitors

Pim3 Inhibitors

  • Pim1
  • Pim2
  • Pim3
Cat.nr. Productnaam Informatie Selectief / Pan IC50 / Ki
S7104 AZD1208 AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3, respectively. Phase 1. Pan Pim3, IC50: 1.9 nM
S7041 CX-6258 HCl CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. Pan Pim3, IC50: 16 nM
S2198 SGI-1776 free base SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. Pan Pim3, IC50: 69 nM