Home MAPK -Protein Tyrosine Kinase MEK MEK2 Inhibitors

MEK2 Inhibitors

  • MEK1
  • MEK1/2
  • MEK2
  • MEK5
Cat.nr. Productnaam Informatie Selectief / Pan IC50 / Ki
S2673 Trametinib (GSK1120212) Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Pan MEK2, IC50: 1.8 nM
S1020 PD184352 (CI-1040) PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5. Phase 2. Pan MEK2, IC50: 17 nM
S1089 Refametinib (RDEA119, Bay 86-9766) Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. Pan MEK2, IC50: 47 nM
S1102 U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. Pan MEK2, IC50: 0.06 μM
S1066 SL-327 SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier. Pan MEK2, IC50: 0.22 μM