Home GPCR & G Protein Endothelin Receptor ET-ASelectief Antagonists

ET-ASelectief Antagonists

  • ET-A
  • ET-B
Cat.nr. Productnaam Informatie Selectief / Pan IC50 / Ki
S8051 Macitentan Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM. Selective ET-A, IC50: 0.5 nM
S4220 Bosentan Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Selective ET-A, Ki: 4.7 nM
S3051 Bosentan Hydrate Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Selective ET-A, Ki: 4.7 nM
S1456 Zibotentan (ZD4054) Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. Selective ET-A, IC50: 21 nM
S2097 Ambrisentan Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH). Selective