Home DNA Damage/DNA Repair Topoisomerase Topo ISelectief Inhibitors

Topo ISelectief Inhibitors

Cat.nr.	Productnaam	Informatie	Selectief / Pan	IC50 / Ki
S1231	Topotecan HCl	Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.	Selective	Topo I (DU-145 Luc cells), IC50: 2 nM; Topo I (MCF-7 Luc cells), IC50: 13 nM
S1288	Camptothecin	Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2.	Selective	Topo I, IC50: 0.68 μM
S3603	Betulinic acid	Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.	Selective	Eukaryotic topoisomerase I, IC50: 5 μM
S2423	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.	Selective
S2217	Irinotecan HCl Trihydrate	Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.	Selective
S4908	SN-38	SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.	Selective
S7261	Beta-Lapachone	Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.	Selective
S1198	Irinotecan	Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.	Selective
S1327	Ellagic acid	Ellagic acid has antiproliferative and antioxidant property.	Pan