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mGluR5-Sélectif Agonists | Antagonists

N° de cat.	Nom du produit	Informations	Sélectif / Pan	IC50 / Ki
S2861	CTEP (RO4956371)	CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.	Selective	mGlu5, IC50: 2.2 nM
S2795	VU 0357121	VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.	Selective	mGluR5, EC50: 30 nM
S2809	MPEP	MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.	Selective	mGluR5, IC50: 36 nM
S2690	ADX-47273	ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.	Selective	mGlu5, EC50: 0.17 μM